Hoare, Sam: search on Z-Library

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1

Receptor binding kinetics equations: Derivation using the Laplace transform method

Hoare, Sam R.J.

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 778 KB

english, 2017

2

Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 459 KB

english, 2005

3

Diet and Mental Health During Emerging Adulthood: A Systematic Review

Collins, Sam, Dash, Sarah, Allender, Steven, Jacka, Felice, Hoare, Erin

Journal:

Emerging Adulthood

Year:

2020

File:

PDF, 476 KB

2020

4

G-protein-coupled receptors: what limits high-affinity agonist binding?

Journal:

Trends in Pharmacological Sciences

Year:

2000

Language:

english

File:

PDF, 63 KB

english, 2000

5

Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor

Wanlong Jiang, Fabio C. Tucci, Joe A. Tran, Beth A. Fleck, Jenny Wen, Stacy Markison, Dragan Marinkovic, Caroline W. Chen, Melissa Arellano, Sam R. Hoare, Michael Johns, Alan C. Foster, John Saunders,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 129 KB

english, 2007

6

Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor

Sam R.J. Hoare, Brock T. Brown, Mark A. Santos, Siobhan Malany, Stephen F. Betz, Dimitri E. Grigoriadis

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 676 KB

english, 2006

7

Molecular Interactions of Nonpeptide Agonists and Antagonists with the Melanocortin-4 Receptor

Fleck, Beth A., Chen,, Yang, Weidong, Huntley, Rajesh, Markison, Stacy, Nickolls, Sarah A., Foster, Alan C., Hoare, Sam R. J.

Journal:

Year:

2005

Language:

english

File:

PDF, 381 KB

english, 2005

8

Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure–activity relationships and insurmountable antagonism

Susan K. Sullivan, Sam R.J. Hoare, Beth A. Fleck, Yun-Fei Zhu, Christopher E. Heise, R. Scott Struthers, Paul D. Crowe

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 655 KB

english, 2006

9

664. Selectivity of Valbenazine (NBI-98854) and Its Major Metabolites on Presynaptic Monoamine Transport

Harriott, Nicole, Hoare, Sam, Grigoriadis, Dimitri

Journal:

Biological Psychiatry

Year:

2017

Language:

english

File:

PDF, 43 KB

english, 2017

10

Quantitative cell membrane-based radioligand binding assays for parathyroid hormone receptors

Sam R.J Hoare, Ted B Usdin

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

1999

Language:

english

File:

PDF, 149 KB

english, 1999

11

Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties

John E. Tellew, Marion Lanier, Manisha Moorjani, Emily Lin, Zhiyong Luo, Deborah H. Slee, Xiaohu Zhang, Sam R.J. Hoare, Dimitri E. Grigoriadis, Yves St. Denis, Romano Di Fabio, Enza Di Modugno, John S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.76 MB

english, 2010

12

Ligand Affinity for Amino-Terminal and Juxtamembrane Domains of the Corticotropin Releasing Factor Type I Receptor: Regulation by G-Protein and Nonpeptide Antagonists

Hoare, Sam R. J., Sullivan, Sue K., Schwarz, David A., Ling, Nicholas, Vale, Wylie W., Crowe, Paul D., Grigoriadis, Dimitri E.

Journal:

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

13

The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF1 receptor antagonist program

Hoare, Sam R.J., Fleck, Beth A., Williams, John P., Grigoriadis, Dimitri E.

Journal:

Drug Discovery Today

Year:

2019

Language:

english

File:

PDF, 614 KB

english, 2019

14

Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity

Sam R.J. Hoare, Susan K. Sullivan, Jun Fan, Khamkeo Khongsaly, Dimitri E. Grigoriadis

Journal:

Year:

2005

Language:

english

File:

PDF, 553 KB

english, 2005

15

Association of Child and Adolescent Mental Health With Adolescent Health Behaviors in the UK Millennium Cohort

Hoare, Erin, Werneck, Andre O., Stubbs, Brendon, Firth, Joseph, Collins, Sam, Corder, Kirsten, van Sluijs, Esther M. F.

Journal:

JAMA Network Open

Year:

2020

File:

PDF, 746 KB

2020

16

Bioconcentration of triclosan and methyl-triclosan in marine mussels (Mytilus galloprovincialis) under laboratory conditions and in metropolitan waters of Gulf St Vincent, South Australia

Kookana, Rai S., Shareef, Ali, Fernandes, Milena B., Hoare, Sonja, Gaylard, Sam, Kumar, Anu

Journal:

Marine Pollution Bulletin

Year:

2013

Language:

english

File:

PDF, 691 KB

english, 2013

17

Evaluating the Ligand Specificity of Zebrafish Parathyroid Hormone (PTH) Receptors: Comparison of PTH, PTH-Related Protein, and Tuberoinfundibular Peptide of 39 Residues

Hoare, Sam R. J., Rubin, David A., Jüppner, Harald, Usdin, Ted B.

Journal:

Year:

2000

Language:

english

File:

PDF, 168 KB

english, 2000

18

666. VMAT2 Inhibition: A Novel Mechanism for Maintained Efficacy at Lowered Antipsychotic Doses

Grigoriadis, Dimitri, Hoare, Sam, Kudwa, Andrea, Boikess, Steve

Journal:

Biological Psychiatry

Year:

2017

Language:

english

File:

PDF, 59 KB

english, 2017

19

Conformational states of the corticotropin releasing factor 1 (CRF1) receptor: detection, and pharmacological evaluation by peptide ligands

Sam R.J Hoare, Susan K Sullivan, Anil Pahuja, Nicholas Ling, Paul D Crowe, Dimitri E Grigoriadis

Journal:

Year:

2003

Language:

english

File:

PDF, 296 KB

english, 2003

20

Design, Synthesis, In Vitro, and In Vivo Characterization of Phenylpiperazines and Pyridinylpiperazines as Potent and Selective Antagonists of the Melanocortin-4 Receptor

Tran, Joe A., Jiang, Wanlong, Tucci, Fabio C., Fleck, Beth A., Wen, Jenny, Sai, Yang, Madan, Ajay, Chen, Ta Kung, Markison, Stacy, Foster, Alan C., Hoare, Sam R., Marks, Daniel, Harman, John, Chen, Ca

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 438 KB

english, 2007

21

Specificity and stability of a new PTH1 receptor antagonist, mouse TIP(7–39)

Sam R.J Hoare, Ted B Usdin

Journal:

Year:

2002

Language:

english

File:

PDF, 219 KB

english, 2002

22

Phenylguanidines as Selective Nonpeptide Melanocortin-5 Receptor Antagonists

Chen,, Yu, Jinghua, Fleck, Beth A., Hoare, Sam R. J., Saunders, John, Foster, Alan C.

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 86 KB

english, 2004

23

A potent and selective nonpeptide antagonist of the melanocortin-4 receptor induces food intake in satiated mice

Joseph Pontillo, Joseph A. Tran, Stacy Markison, Margaret Joppa, Beth A. Fleck, Dragan Marinkovic, Melissa Arellano, Fabio C. Tucci, Marion Lanier, Jodie Nelson, John Saunders, Sam R.J. Hoare, Alan C.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 152 KB

english, 2005

24

Synthesis and characterization of pyrrolidine derivatives as potent agonists of the human melanocortin-4 receptor

Wanlong Jiang, Joe A. Tran, Fabio C. Tucci, Beth A. Fleck, Sam R. Hoare, Stacy Markison, Jenny Wen, Caroline W. Chen, Dragan Marinkovic, Melissa Arellano, Alan C. Foster, Chen Chen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 265 KB

english, 2007

25

The Discrepancy Between the Binding Affinity of PTH (1–34) and RS 66271 is Explained by Interaction of the PTH/PTHrP Receptor With G-Protein

Sam R. J. Hoare, Ted B. Usdin

Journal:

Journal of Bone and Mineral Research

Year:

2000

Language:

english

File:

PDF, 44 KB

english, 2000

26

Discovery of 1-{2-[(1 S )-(3-Dimethylamino-propionyl)amino-2-methylpropyl]-4-methyl-phenyl}-4-[(2 R )-methyl-3-(4-chlorophenyl)-propionyl]piperazine as an Orally Active Antagonist of the Melanocortin-4 Receptor for the Potential Treatment of Cachexia

Chen,, Jiang, Wanlong, Tucci, Fabio, Tran, Joe A., Fleck, Beth A., Hoare, Sam R., Joppa, Margaret, Markison, Stacy, Wen, Jenny, Sai, Yang, Johns, Michael, Madan, Ajay, Chen, Takung, Chen, Caroline W.

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 67 KB

english, 2007

27

Analytical method for simultaneously measuring ex vivo drug receptor occupancy and dissociation rate: Application to (R)-dimethindene occupancy of central histamine H 1 receptors

Malany, Siobhan, Hernandez, Lisa M., Smith, William F., Crowe, Paul D., Hoare, Sam R. J.

Journal:

Journal of Receptor and Signal Transduction Research

Year:

2009

Language:

english

File:

PDF, 979 KB

english, 2009

28

Allosteric Modulators of Class B G-Protein-Coupled Receptors

Journal:

Current Neuropharmacology

Year:

2007

Language:

english

File:

PDF, 536 KB

english, 2007

29

The importance of target binding kinetics for measuring target binding affinity in drug discovery: a case study from a CRF1 receptor antagonist program

Hoare, Sam R.J., Fleck, Beth A., Williams, John P., Grigoriadis, Dimitri E.

Journal:

Drug Discovery Today

Year:

2019

File:

PDF, 614 KB

2019

30

A kinetic method for measuring agonist efficacy and ligand bias using high resolution biosensors and a kinetic data analysis framework

Hoare, Sam R. J., Tewson, Paul H., Quinn, Anne Marie, Hughes, Thomas E.

Journal:

Scientific Reports

Year:

2020

Language:

english

File:

PDF, 2.68 MB

english, 2020

31

Pharmacological characterisation of novel adenosine A3 receptor antagonists

Barkan, Kerry, Lagarias, Panagiotis, Stampelou, Margarita, Stamatis, Dimitrios, Hoare, Sam, Safitri, Dewi, Klotz, Karl-Norbert, Vrontaki, Eleni, Kolocouris, Antonios, Ladds, Graham

Journal:

Scientific Reports

Year:

2020

File:

PDF, 2.92 MB

2020

32

The Regulation of Feeding and Metabolic Rate and the Prevention of Murine Cancer Cachexia with a Small-Molecule Melanocortin-4 Receptor Antagonist

Markison, Stacy, Foster, Alan C., Chen, Chen, Brookhart, Gregor B., Hesse, Amy, Hoare, Sam R. J., Fleck, Beth A., Brown, Brock T., Marks, Daniel L.

Journal:

Year:

2005

Language:

english

File:

PDF, 243 KB

english, 2005

33

Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites

Grigoriadis, Dimitri E., Smith, Evan, Hoare, Sam R.J., Madan, Ajay, Bozigian, Haig

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2017

Language:

english

File:

PDF, 665 KB

english, 2017

34

Pharmacological and pharmacokinetic characterization of 2-piperazine-α-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists

Chen Chen, Fabio C. Tucci, Wanlong Jiang, Joe A. Tran, Beth A. Fleck, Sam R. Hoare, Jenny Wen, Takung Chen, Michael Johns, Stacy Markison, Alan C. Foster, Dragan Marinkovic, Caroline W. Chen, Melissa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 328 KB

english, 2008

35

Identification and characterization of pyrrolidine diastereoisomers as potent functional agonists and antagonists of the human melanocortin-4 receptor

Chen Chen, Wanlong Jiang, Joe A. Tran, Fabio C. Tucci, Beth A. Fleck, Stacy Markison, Jenny Wen, Ajay Madan, Sam R. Hoare, Alan C. Foster, Dragan Marinkovic, Caroline W. Chen, Melissa Arellano, John S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 199 KB

english, 2008

36

Analyzing kinetic signaling data for G-protein-coupled receptors

Hoare, Sam R. J., Tewson, Paul H., Quinn, Anne Marie, Hughes, Thomas E., Bridge, Lloyd J.

Journal:

Scientific Reports

Year:

2020

File:

PDF, 2.97 MB

2020

37

The distribution of triclosan and methyl-triclosan in marine sediments of Barker Inlet, South Australia

Fernandes, Milena, Shareef, Ali, Kookana, Rai, Gaylard, Sam, Hoare, Sonja, Kildea, Tim

Journal:

Journal of Environmental Monitoring

Year:

2011

Language:

english

File:

PDF, 197 KB

english, 2011

38

Sa1207 - Prospective Observational Cohort Study of Rapid Ionization Mass Spectrometry (Reims) for Near-Real Time Diagnosis and Stratification of Colorectal Cancer

Mason, Sam, Alexander, James L., White, Emma, Bodai, Zsolt, Manoli, Eftychios, Paizs, Petra, Scott, Alasdair, Adebesin, Afeez, Hoare, Jonathan, Goldin, Robert, Darzi, Ara, Takats, Zoltan, Kinross, Jam

Journal:

Gastroenterology

Year:

2018

Language:

english

File:

PDF, 1.02 MB

english, 2018

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